Chemical Biology Lab Manager
Dr Susan Gannon
I have worked in University of Glasgow for the past 8 years, I completed both my Phd entitled “Free radical mediated stress in Plant Cancers” in 2006 and undergraduate degree at Abertay University in Dundee.
My role within the group is to keep a good overview on the day to day operation of the lab, ensure students are working safely and check the equipment is in good working order, and that procedures are in place to insure the smooth running of the lab. I also participate in peptide synthesis for a number of collaborations we have within the group. Having a background and experience in biological subjects I will also provide the students with training in various biological techniques.
tel: 0141 330 3543
tel 0141 330 3243
Postdoctoral Research Associate
Dr Alex Hoose
Alex Hoose obtained his Masters degree in Chemistry from the University of Durham, UK (2010). He subsequently worked in peptide production at Cambridge Research Biochemicals, prior to undertaking pharmaceutical research at Medimmune into the development of peptides for the treatment of neuropathic pain and diabetes. He subsequently obtained his PhD in Biochemistry from the University of Southampton, UK (2016) where he conducted research into cap-dependent translation inhibitors in collaboration with Dr. Mark Coldwell. Alex then conducted post-Doctoral research (2016-2017) focussed on the development of peptide metalloprotease inhibitors under the supervision of Dr. Andrew Jamieson. He is currently a Post Doctoral Research Associate (2017-present) in the group of Prof. Rob Liskamp. His research interests include the application of peptides as pesticides, pharmaceuticals and tools for the development of antibody-drug conjugates.
I come from Krakow, Poland where I studied Pharmacy at the Jagiellonian University. However, I became interested in medicinal chemistry firstly during my Master thesis in Poland and later on during my Erasmus internship at Utrecht University in The Netherlands.
The main aim of my PhD project is to optimize the design of the HIV envelope gp120 protein mimics which will be followed by various studies of their structure and binding properties to their natural ligand – the CD4 receptor (both biophysical and biological assays). Depending on the results of these studies, the opportunities for development of a synthetic vaccine will be considered.
I am from Renfrew, Scotland and I graduated from the University of Glasgow in July 2015 with an MSci in Chemistry. As part of my undergraduate I spent a year with the BIOSYN research group at Leiden University, the Netherlands, working on the development of β2 specific proteasome inhibitors incorporating non-natural amino acids. This quite naturally led on to my Masters project when I returned to Glasgow, which was based on sulfonyl fluorides as proteasome inhibitors, within the Liskamp group. The interesting work that I saw taking place within the group as well as their excellent facilities encouraged me to seek a PhD position with them.
My PhD project is based on cysteine protease and protein phosphatase inhibitors utilising a new ‘warhead’ for trapping active site nucleophiles.
If you don’t find me doing chemistry then I am probably in a café somewhere eating cake, or on a bike cycling to a café somewhere to eat cake. I tend to jump between hobbies in my spare time to keep life interesting trying anything that sounds good from climbing to skiing. Cake has always been a constant.
Originally, I am from Berlin, Germany but my university education took place in Göttingen, Germany where I also had my first insights in the field of peptide chemistry.
My Phd in Glasgow encompasses two different projects.
My first project takes place as cooperation with the Beatson Institute in Glasgow. I design and synthesise peptides which bind to the protein mdm2 and therefore deactivates its ligase functionality. For this reason the tumour suppressor p53 gets activated which could lead to a novel therapeutic treatment against cancer.
For my second project, a collaboration with the School of Engineering, I modify polymeric surfaces with peptides which is the base for a controlled and well defined environment for stem cell culturing.
The largest part of my previous education took place in The Netherlands, were I was also born. After living in Nijmegen for 18 years I moved to Utrecht where I finished a bachelor in Chemistry and a master in Drug Innovation, both at Utrecht University. During my master I focused mostly on medicinal chemistry, however, I have also had the opportunity to do a research internship at the Scripps Research Institute in La Jolla, California, where I focused more on Biochemistry. The combination of these two fields is present in my current PhD project as well. To underline this dual nature of my project, I am actually positioned in two groups, the Molecular pharmacoly group, led by Professor Milligan and the Chemical Biology and Medicinal Chemistry group, led by Professor Liskamp. The goal of my project is to synthesize a molecular probe that can be used to identify unknown receptors for certain ligands by means of proteomics. The main receptor that I would like to identity is that of the Bacteroides fragilis toxin, a toxin secreted by certain bacteria in the gut that has recently been linked to colon cancer
I come from the Czech Republic where I also did my bachelor and master studies, both in the field of chemistry of natural compounds, at the Institute of Chemical Technology (ITC) in Prague. My work was mainly focused on the chemistry of steroids during my time at ICT. However, I also spent 5 months at Utrecht University in the Netherlands where I worked on mimics of the peptide antibiotic vancomycin under the supervision of Prof Liskamp. I then followed Prof Liskamp to Glasgow to undertake a PhD project.
The aim of my PhD project is to prepare medium-sized molecules targeting tumour necrosis factor alpha (TNFα) – a protein which may cause autoimmune diseases. To achieve this goal I combine chemistry of small molecules along with peptide chemistry to obtain molecules mimicking parts of already existing, monoclonal antibody based drugs against TNFα.
Born in The Netherlands were I have finished a Bachelor degree in Chemistry and a Masters degree in Molecular and Cellular Life Sciences at the University of Utrecht.
During the time of my Masters education I was able to do an internship at the Faculty of Veterinary Medicine, Division of Virology at the University of Utrecht were I was allowed to explore various techniques involved in Virology and Life Science research. In addition, I was able to do an internship at the Department of Medicinal Chemistry, Science Faculty at the University of Utrecht were I got the opportunity to obtain the necessary skills involved in Peptide Chemistry and Epitope Mimicry research.
Currently, I have been granted the opportunity to combine my previous experiences within a PhD project at the Chemical Biology and Medicinal Chemistry Department at the University of Glasgow, in collaboration with Dr. Patel of the University of Glasgow Centre for Virus Research, supervised by Professor Liskamp. Within this project I aim to investigate the immunogenic potential of peptides from the Hepatitis C Virus Envelope protein. After which, the aim is to design epitope mimics towards a potential synthetic vaccine.
I came to Scotland five years ago to start my undergraduate degree after finishing high school in Latvia. I have recently received my MSci degree in Chemistry with Medicinal Chemistry from the University of Glasgow. During my studies I spent one year doing an industrial medicinal chemistry internship at Eisai, working on two separate projects concerning allosteric modulation of GPCR’s for the treatment of neurological disorders.
I completed my final year project in the Liskamp group designing and testing novel peptide cyclisation linkers. I found the environment in the group welcoming and the research exciting, so I decided to pursue my PhD here. The aim of my project is to modify DNA and RNA backbone in order to make oligonucleotides with improved pharmaceutical properties.
Dr Stephen Morrison, PhD from 2013-2017
Dr Ezequiel Silva Nigenda, PhD from 2014-2017
Dr Natalia Herrero Alvarez, PhD from 2013-2017
Dr Raik Artschwager, PhD from 2013-2017
Clémentine Pescheteau, Erasmus Student from Chimie Paris Tech, 2017
Dr Helmus van de Langemheen, Postdoctoral research associate, 2014-2016
Dr Tobias Postma, Postdoctoral research associate, 2014-2016
Dr Hanna Radzey, Postdoctoral research associate, 2015-2016
Anne Coenen, Erasmus Student from Radboud University Nijmegen, 2015
Ariadna Ruiz Lobo, MSc, 2014-2015
Jessica Münch, Erasmus Student from University of Applied Sciences, Utrecht, 2015
Joachim Bijl, Erasmus Student from University of Applied Sciences, Utrecht, 2015
Olaf Fuchs, Erasmus Student from Humboldt University, Berlin, 2015
Joschka Holzhäuser, Erasmus Student from the University of Aachen, 2015
Rob Luteijn, Erasmus Student from the University of Utrecht, 2014
Felicitas Bröhl, Erasmus Student from the University of Cologne, 2013