Chemical Biology Lab Manager
I have worked in University of Glasgow for the past 8 years, I completed both my Phd entitled “Free radical mediated stress in Plant Cancers” in 2006 and undergraduate degree at Abertay University in Dundee.
My role within the group is to keep a good overview on the day to day operation of the lab, ensure students are working safely and check the equipment is in good working order, and that procedures are in place to insure the smooth running of the lab. I also participate in peptide synthesis for a number of collaborations we have within the group. Having a background and experience in biological subjects I will also provide the students with training in various biological techniques.
tel: 0141 330 3543
I come from Krakow, Poland where I studied Pharmacy at the Jagiellonian University. However, I became interested in medicinal chemistry firstly during my Master thesis in Poland and later on during my Erasmus internship at Utrecht University in The Netherlands.
The main aim of my PhD project is to optimize the design of the HIV envelope gp120 protein mimics which will be followed by various studies of their structure and binding properties to their natural ligand – the CD4 receptor (both biophysical and biological assays). Depending on the results of these studies, the opportunities for development of a synthetic vaccine will be considered.
I am from Renfrew, Scotland and I graduated from the University of Glasgow in July 2015 with an MSci in Chemistry. As part of my undergraduate I spent a year with the BIOSYN research group at Leiden University, the Netherlands, working on the development of β2 specific proteasome inhibitors incorporating non-natural amino acids. This quite naturally led on to my Masters project when I returned to Glasgow, which was based on sulfonyl fluorides as proteasome inhibitors, within the Liskamp group. The interesting work that I saw taking place within the group as well as their excellent facilities encouraged me to seek a PhD position with them.
My PhD project is based on cysteine protease and protein phosphatase inhibitors utilising a new ‘warhead’ for trapping active site nucleophiles.
If you don’t find me doing chemistry then I am probably in a café somewhere eating cake, or on a bike cycling to a café somewhere to eat cake. I tend to jump between hobbies in my spare time to keep life interesting trying anything that sounds good from climbing to skiing. Cake has always been a constant.
Originally, I am from Berlin, Germany but my university education took place in Göttingen, Germany where I also had my first insights in the field of peptide chemistry.
My Phd in Glasgow encompasses two different projects.
My first project takes place as cooperation with the Beatson Institute in Glasgow. I design and synthesise peptides which bind to the protein mdm2 and therefore deactivates its ligase functionality. For this reason the tumour suppressor p53 gets activated which could lead to a novel therapeutic treatment against cancer.
For my second project, a collaboration with the School of Engineering, I modify polymeric surfaces with peptides which is the base for a controlled and well defined environment for stem cell culturing.
The largest part of my previous education took place in The Netherlands, were I was also born. After living in Nijmegen for 18 years I moved to Utrecht where I finished a bachelor in Chemistry and a master in Drug Innovation, both at Utrecht University. During my master I focused mostly on medicinal chemistry, however, I have also had the opportunity to do a research internship at the Scripps Research Institute in La Jolla, California, where I focused more on Biochemistry. The combination of these two fields is present in my current PhD project as well. To underline this dual nature of my project, I am actually positioned in two groups, the Molecular pharmacoly group, led by Professor Milligan and the Chemical Biology and Medicinal Chemistry group, led by Professor Liskamp. The goal of my project is to synthesize a molecular probe that can be used to identify unknown receptors for certain ligands by means of proteomics. The main receptor that I would like to identity is that of the Bacteroides fragilis toxin, a toxin secreted by certain bacteria in the gut that has recently been linked to colon cancer
Natalia Herrero Alvarez
I am originally from Madrid, where I completed my bachelor in Chemistry and my master in Biochemistry at the Complutense University. Following that I went to do my Erasmus placement in the Netherlands and a Med-Chem intership at Hoffmann-La Roche in Switzerland. In 2013 I joined Prof. Liskamp’s group as a PhD student, where I am currently working on sufonyl fluorides as protease inhibitors in a project which combines both chemistry and biochemistry.
I come from the Czech Republic where I also did my bachelor and master studies, both in the field of chemistry of natural compounds, at the Institute of Chemical Technology (ITC) in Prague. My work was mainly focused on the chemistry of steroids during my time at ICT. However, I also spent 5 months at Utrecht University in the Netherlands where I worked on mimics of the peptide antibiotic vancomycin under the supervision of Prof Liskamp. I then followed Prof Liskamp to Glasgow to undertake a PhD project.
The aim of my PhD project is to prepare medium-sized molecules targeting tumour necrosis factor alpha (TNFα) – a protein which may cause autoimmune diseases. To achieve this goal I combine chemistry of small molecules along with peptide chemistry to obtain molecules mimicking parts of already existing, monoclonal antibody based drugs against TNFα.
I studied chemistry at the University of Göttingen in Germany accompanied by a student exchange at the University of Manchester. At the end of my studies my interest was focused on biomolecular chemistry and I decided to do my PhD in medicinal chemistry – that is, to synthesize peptides which are effective against cancer, for example.
My PhD thesis is about the specific inhibition of the β1, β2 and β5 subunits of the proteasome and immunoproteasome. Utilizing a sulfonyl fluoride as the electrophilic trap in peptide based inhibitors these can be used to treat fast growing cancers. As a side project I am working on the inhibition of thrombin.
Stephen Morrison is from Glasgow, Scotland. He graduated from the University of Glasgow in July 2013 with an MSci in Medicinal Chemistry, which included an industrial placement at Procter & Gamble’s research institute in Newcastle, England. During his final year as a undergraduate he worked with Dr Richard Hartley on the synthesis of mitochondrial targeted selective uncoupling molecules.
He joined Dr Prunet's group in October 2013, and is currently working on the synthesis of bioactive polymers, which is a conjoined project with Prof Robert Liskamp. Outside of the lab he enjoys running and reading, as well as volunteer work for the British Red Cross.
Born in The Netherlands were I have finished a Bachelor degree in Chemistry and a Masters degree in Molecular and Cellular Life Sciences at the University of Utrecht.
During the time of my Masters education I was able to do an internship at the Faculty of Veterinary Medicine, Division of Virology at the University of Utrecht were I was allowed to explore various techniques involved in Virology and Life Science research. In addition, I was able to do an internship at the Department of Medicinal Chemistry, Science Faculty at the University of Utrecht were I got the opportunity to obtain the necessary skills involved in Peptide Chemistry and Epitope Mimicry research.
Currently, I have been granted the opportunity to combine my previous experiences within a PhD project at the Chemical Biology and Medicinal Chemistry Department at the University of Glasgow, in collaboration with Dr. Patel of the University of Glasgow Centre for Virus Research, supervised by Professor Liskamp. Within this project I aim to investigate the immunogenic potential of peptides from the Hepatitis C Virus Envelope protein. After which, the aim is to design epitope mimics towards a potential synthetic vaccine.
I came to Scotland five years ago to start my undergraduate degree after finishing high school in Latvia. I have recently received my MSci degree in Chemistry with Medicinal Chemistry from the University of Glasgow. During my studies I spent one year doing an industrial medicinal chemistry internship at Eisai, working on two separate projects concerning allosteric modulation of GPCR’s for the treatment of neurological disorders.
I completed my final year project in the Liskamp group designing and testing novel peptide cyclisation linkers. I found the environment in the group welcoming and the research exciting, so I decided to pursue my PhD here. The aim of my project is to modify DNA and RNA backbone in order to make oligonucleotides with improved pharmaceutical properties.
As of 1st October
Ezequiel Silva Nigenda (PhD)
Helmus van de Langemheen, Postdoc, 2014-2016
Tobias Postma, Postdoc, 2014-2016
Hanna Radzey, Postdoc, 2015-2016
Ariadna Ruiz Lobo, 2014-2015
Jessica Münch, Erasmus Student from University of Applied Sciences, Utrecht, 2015
Joachim Bijl, Erasmus Student from University of Applied Sciences, Utrecht, 2015
Olaf Fuchs, Erasmus Student from Humboldt University, Berlin, 2015
Joschka Holzhäuser, Erasmus Student from the University of Aachen, 2015
Rob Luteijn, Erasmus Student from the University of Utrecht, 2014
Felicitas Bröhl, Erasmus Student from the University of Cologne, 2013